Dampak Kebijakan Revitalisasi Pasar Tradisional Terhadap Kondisi Ekonomi Pedagang Pasar Tani Kota Bandar Lampung

The essence of this study is to determine the effect of traditional market revitalization policies on the economic conditions of traders. One of the traditional markets in Bandar Lampung, namely Pasar Tani, is the location of this research. The sample in this study were 67 Farmers Market traders. In this study, questionnaires and interviews were used to collect data. The SPSS 25 regression analysis tool was used to analyze the primary data used in this study. Descriptive approach is the most effective method. According to the findings, data processing has a significant and beneficial effect on economic indicators such as the number of business segments and employment. However, there is one indicator, namely the increase in the income of Farmers Market traders which has decreased after the revitalization

Epstein-Barr Virus and Malaria Interactions: Immunology Perspective

Epstein-Barr Virus can cause various diseases, from acute inflammatory diseases such as fatal or chronic EBV infection, infectious mononucleosis as well as lymphoid and epithelial cancer, various autoimmune diseases, and also could interact with malaria. As EBV infects 95% of the world population, and more than 30% are infected with the protozoan parasite, with more than 500,000 deaths due to malaria cases. It is important to understand how EBV dysregulates the immune system, especially when the virus is interacting with other pathogens such as malaria parasites, causing more severe conditions in certain people like Burkitt Lymphoma. This review will be informative about the mechanism of how EBV interacts with malaria parasites and how it affects the immune system. Knowledge of various cytokines triggering the immune system which may provide links to control/minimize malaria disease severity

Big data assisted CRAN enabled 5G SON architecture

The recent development of Big Data, Internet of Things (IoT) and 5G network technology offers a plethora of opportunities to the IT industry and mobile network operators. 5G cellular technology promises to offer connectivity to massive numbers of IoT devices while meeting low-latency data transmission requirements. A deficiency of the current 4G networks is that the data from IoT devices and mobile nodes are merely passed on to the cloud and the communication infrastructure does not play a part in data analysis. Instead of only passing data on to the cloud, the system could also contribute to data analysis and decision-making. In this work, a Big Data driven self-optimized 5G network design is proposed using the knowledge of emerging technologies CRAN, NVF and SDN. Also, some technical impediments in 5G network optimization are discussed. A case study is presented to demonstrate the assistance of Big Data in solving the resource allocation problem

Time trends in the incidence of cancer cervix in Karachi South, 1995-2002

Introduction:The objective of the study was to determine the trends of cancer cervix in Karachi South during an eight (1995-2002) year period. Methododology: Cancer cervix cases recorded at Karachi Cancer Registry during 1st January 1995 to 31st December 2002 were analyzed. Trends were studied by analyzing the age standardized incidence rates (ASR)s in 2 time periods, 1995-97 and 1998-2002. Results: Cancer cervix ranked sixth in the 1995-97 period the age standardized incidence rate (ASR) world and crude incidence rate (CIR) per 100,000 were 6.81 and 3.22. It reached the fifth ranking in the 1998-2002 period with an ASR and CIR of 7.5 and 4.0 per 100,000. Thus between 1995 and 2002, the incidence of cervical cancer registered an approximate 10% increase. The mean age of the cancer cases was 53.3 years (SD 11.6, 95% CI 50.58, 55.96, range 32-85 years) and 50.7 years (SD 11.7, 95% CI 48.8, 52.5, range 51 years) in period 1 and 2 respectively. The morphological components of squamous cell carcinoma and adenocarcinoma remained stable during this period, though a marginally higher component and increasing incidence of adenocarcinoma was observed throughout. A negligible down staging was observed in the 1998-2002 period. Localized malignancy was observed in 30.8% in period 2 as compared to 25.7% in period 1 and the component of carcinoma in situ increased from 0% percent in period 1 to 1.3% in the second period. Despite this two thirds of the cases still presented with a regional or distant spread of disease. Conclusion: Pakistan at present falls into a low risk cancer cervix region. The cause of concern is the steadily increasing incidence especially in the younger birth cohorts, the advanced disease at presentation, insignificant in-situ cancers and no preventive intervention or awareness practices in place

Magnetoresistance and magneto-plasmonic sensors for the detection of cancer biomarkers : A bibliometric analysis and recent advances

The conventional approaches to diagnosing cancer are expensive, often involve exposure to radiation, and struggle to identify early-stage lung cancer. As a result, the five-year survival rate is significantly reduced. Fortunately, promising alternatives using magnetoresistance (MR) and magneto-plasmonic sensors have emerged for swiftly, accurately, and inexpensively detecting cancer in its initial phases. These sensor technologies offer numerous advantages over their counterparts, such as minimal background noise, immunity to environmental influences, compatibility with nanofabrication methods, ability to detect multiple substances simultaneously, straightforward integration, high specificity, distinctive identifying capabilities, real-time monitoring, stability, label-free detection, and remarkable sensitivity for detecting individual molecules. Nevertheless, since the use of these techniques for cancer biomarker detection is relatively new, it is essential to conduct a bibliometric analysis and review recent literature to offer guidance to both early-career and established researchers in this domain. Consequently, this study performs a scientometric evaluation of the literature related to cancer biomarker detection using MR and magneto-plasmonic methods. The objective is to pinpoint current preferred techniques and challenges by examining statistics such as publication numbers, authors, countries, journals, and research interests. Furthermore, the paper also presents the latest advancements in MR and magneto-plasmonic sensors for cancer biomarker detection, with a focus on the last decade. In addition, an overview of the ongoing research in the field of MR and magneto-plasmonic sensors for detecting cancer biomarkers is highlighted. Finally, a summary on the level of current research including the significant accomplishments, challenges, and outlooks of MR and magneto-plasmonic sensors for the detection of cancer biomarkers are highlighted

Cross-sectional study of availability and pharmaceutical quality of antibiotics requested with or without prescription (Over The Counter) in Surabaya, Indonesia

Contains fulltext : 87881.pdf (publisher's version ) (Open Access

Endemic and emerging acute virus infections in Indonesia: an overview of the past decade and implications for the future

Being the largest archipelago country in the world, with a tropical climate and a unique flora and fauna, Indonesia habitats one of the most diverse biome in the world. These characteristics make Indonesia a popular travel destination, with tourism numbers increasing yearly. These characteristics also facilitate the transmission of zoonosis and provide ideal living and breading circumstances for arthropods, known vectors for viral diseases. A review of the past 10 years of literature, reports of the Ministry of Health, Republic of Indonesia and ProMED-mail shows a significant increase in dengue infection incidence. Furthermore, chikungunya, Japanese encephalitis and rabies are proven to be endemic in Indonesia. The combination of cohort studies, governmental data and ProMED-mail reveals an integrated overview for those working in travel medicine and public health, focusing on both endemic and emerging acute virus infections. This review summarizes the epidemiology of acute virus infections in Indonesia, including outbreak reports, as well as public health response measurements and their potential or efficacy. Knowledge about human behavio

Fluoroquinolone-resistant Escherichia coli, Indonesia

High prevalence may be due to clonal spread and emergence of resistant strains

Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial

BACKGROUND: Passive immunotherapy using hyperimmune intravenous immunoglobulin (hIVIG) to SARS-CoV-2, derived from recovered donors, is a potential rapidly available, specific therapy for an outbreak infection such as SARS-CoV-2. Findings from randomised clinical trials of hIVIG for the treatment of COVID-19 are limited. METHODS: In this international randomised, double-blind, placebo-controlled trial, hospitalised patients with COVID-19 who had been symptomatic for up to 12 days and did not have acute end-organ failure were randomly assigned (1:1) to receive either hIVIG or an equivalent volume of saline as placebo, in addition to remdesivir, when not contraindicated, and other standard clinical care. Randomisation was stratified by site pharmacy; schedules were prepared using a mass-weighted urn design. Infusions were prepared and masked by trial pharmacists; all other investigators, research staff, and trial participants were masked to group allocation. Follow-up was for 28 days. The primary outcome was measured at day 7 by a seven-category ordinal endpoint that considered pulmonary status and extrapulmonary complications and ranged from no limiting symptoms to death. Deaths and adverse events, including organ failure and serious infections, were used to define composite safety outcomes at days 7 and 28. Prespecified subgroup analyses were carried out for efficacy and safety outcomes by duration of symptoms, the presence of anti-spike neutralising antibodies, and other baseline factors. Analyses were done on a modified intention-to-treat (mITT) population, which included all randomly assigned participants who met eligibility criteria and received all or part of the assigned study product infusion. This study is registered with ClinicalTrials.gov, NCT04546581. FINDINGS: From Oct 8, 2020, to Feb 10, 2021, 593 participants (n=301 hIVIG, n=292 placebo) were enrolled at 63 sites in 11 countries; 579 patients were included in the mITT analysis. Compared with placebo, the hIVIG group did not have significantly greater odds of a more favourable outcome at day 7; the adjusted OR was 1·06 (95% CI 0·77–1·45; p=0·72). Infusions were well tolerated, although infusion reactions were more common in the hIVIG group (18·6% vs 9·5% for placebo; p=0·002). The percentage with the composite safety outcome at day 7 was similar for the hIVIG (24%) and placebo groups (25%; OR 0·98, 95% CI 0·66–1·46; p=0·91). The ORs for the day 7 ordinal outcome did not vary for subgroups considered, but there was evidence of heterogeneity of the treatment effect for the day 7 composite safety outcome: risk was greater for hIVIG compared with placebo for patients who were antibody positive (OR 2·21, 95% CI 1·14–4·29); for patients who were antibody negative, the OR was 0·51 (0·29–0·90; pinteraction=0·001). INTERPRETATION: When administered with standard of care including remdesivir, SARS-CoV-2 hIVIG did not demonstrate efficacy among patients hospitalised with COVID-19 without end-organ failure. The safety of hIVIG might vary by the presence of endogenous neutralising antibodies at entry. FUNDING: US National Institutes of Health